Historical Uses and Clinical Studies

Ginger RhizomesGinger has been used for morning sickness, motion sickness, nausea, vomiting, drug related, upset stomach, flatulence and nausea caused by general anesthesia after surgery

Gingerols and shogaols, the active ingredients in Zindol® DS have a wide range of applications: morning sickness, motion sickness, upset stomach caused by general anesthesia after surgery, and anticipatory nausea brought on by certain medical treatments (such as chemotherapy).

Historical Uses

Ginger, an ancient spice mentioned in both the Bible and the Koran, is most known for its role as a flavoring agent for food in Asian and Indian recipes as well as for medicinal conditions such as headaches, nausea, rheumatism and colds for over two millennia.

  • Chemotherapy Induced Nausea and Vomiting
    Despite the widespread use of the new block buster anti-emetic medications (i.e. 5-HT3 receptor antagonist anti-emetics), chemotherapy induced nausea and vomiting (CINV) continues to be reported by up to 70% of adult patients.  Clinical studies have demonstrated that certain ginger extracts are significantly effective in reducing chemotherapy induced nausea without any adverse side effects.

  • Pregnancy-Related Nausea and Vomiting
    Pregnancy related nausea and vomiting (PRNV) or morning sickness also called Nausea Gravidarum is a condition that affects more than 50% of all pregnant women. Ginger extracts have been clinically studied for their ability to alleviate pregnancy-related nausea and vomiting.

  • Motion Sickness Nausea and Vomiting
    About 33% of people are susceptible to motion sickness related nausea and vomiting (MRNV) even in mild conditions, while nearly 66% of people are susceptible in more severe conditions. Clinical studies have shown that extracts of ginger drastically diminishes the symptoms.

  • Post-Operative Nausea and Vomiting
    Post-operative nausea and vomiting (PONV) is primarily caused by anesthesia and other drugs used in surgical procedures, much of which is elective in the United States.  Clinical studies have shown that certain ginger extracts may be a safe and effective way of calming post-operative nausea.