Pharmacology and Nonclinical Research

Research indicates that the bioactive ingredients of ginger, gingerols and shogaols, have anti-emetic anti-inflammatory, anticancer, antimicrobial and antioxidant properties

ZindolDS CINV ZindolDS ChemotherapyGingerols and Shogaols, the active ingredients in the ginger extract that comprises Zindol® DS, have a number of important biological effects. From anti-inflammatory and antimicrobial activity to antioxidant effects and protection against radiation, ginger’s effects are potent and varied.

Nonclinical animal studies examining the effects of ginger have produced considerable data on the pharmacology of ginger and its active constituents.

  • Anticancer Activity
    Bioactive constituents of ginger such as 6-shogaol have shown potent in vitro and in vivo anticancer activity against ovarian, liver, colon and other cancers.

  • Anti-Inflammatory and Analgesic Activities
    Nonclinical studies have confirmed anti-inflammatory, analgesic, antipyretic, anti-platelet and COX-1 inhibition activities of ginger extracts that mimic dual-acting NSAIDs.

  • Antimicrobial Activity
    Ginger extracts have shown dose dependent antimicrobial activities against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans.

  • Antioxidant Effects
    Ginger and 6-gingerol have exhibited strong antioxidant action both in vivo and in vitro, in addition to strong anti-inflammatory and anti-apoptotic actions.

  • Effect on Lipid and Glucose
    Nonclinical studies suggest that ginger extracts may be useful for controlling lipid levels, bodyweight, hyperglycemia, and insulin sensitivity and treating diabetes.

  • Effect on Blood Clotting
    Nonclinical studies suggest that ginger extracts may be useful as anti-thrombotic and anti-inflammatory agent and may impact the cardiovascular system.

  • Effect on Blood Pressure
    Nonclinical studies suggest that ginger extracts exert many direct and indirect effects on high blood pressure, angina, arrhythmia and heart rate.

  • Effect on Gastrointestinal Tract
    Ginger extracts have been shown to have an anti-serotonin effect mediated by 5-HT3 receptors and to be effective against nausea and emesis (vomiting).

  • Protection Against Radiation Sickness
    Ginger extracts may be a safe and effective way of calming nausea and vomiting related to radiation sickness at appropriate dosing and schedule.

  • Tissue and Radio-Protective Effects
    Nonclinical studies suggest that ginger extracts may reduce severity of gastrointestinal syndrome and mitigate early damage produced in cells and tissues by ionizing radiation.