Zindol® DS - Motion Sickness Related Nausea and Vomiting (MRNV)

A safe and effective way of calming nausea and vomiting related to of motion sickness, drastically diminishing symptoms

Motion Sickness Related Nausea and Vomiting (MRNV)

About 33% of people are susceptible to motion sickness related nausea and vomiting (MRNV) even in mild conditions such as traveling by boat on a calm sea, while nearly 66% of people are susceptible in more severe conditions.

Rough SailingMRNV is caused by a disconnection between visual perception and the perception of body position and movement.  When the brain senses motion but the eye sees none, the body automatically reacts to get rid of this neurotoxin resulting in nausea and, in extreme cases, vomiting.  Vomiting, however, does not necessarily ease the nausea due to motion sickness.

Motion sickness is often referred to as seasickness, car sickness, simulation sickness or air sickness.  Other causes of motion sickness include amusement park rides, spinning actions, films and other video, and space travel.  About 60% of space shuttle astronauts experience MRNV in their first flight.

Ginger Can Ease MRNV

Ginger is believed to be the only botanical that drastically diminishes the symptoms of motion sickness as demonstrated in studies dating back to 1982 (Mowrey, 1982; Kirchdorfer, 1983; Careddu, 1986) with some positive results.

More recent research efforts, which include seven clinical trials examining the effects of ginger for motion sickness, have demonstrated less effectiveness with only three (Grontved, 1988; Schmid, 1991; Lien et al., 2003).

In two randomized control studies that compared standard of care drugs for prevention of motion sickness, ginger proved to be as effective as the other frequently prescribed medications (Riebenfeld et al., 1986 and Schmid et al., 1994). In a simulated motion sickness study, Stewart et al. (1991) determined that ginger did not possess any anti-motion function.

Holtmann et al.’s work (1989) suggests that ginger has no influence on the experimentally induced nystagmus but its effectiveness may be derived from the influence of the ginger root agents on the gastric system.

Zindol® DS for Motion Sickness Related Nausea and Vomiting (MRNV)

Zindol® DS, with appropriate dosing and schedule for anticipated nausea, may be a safe and effective way of calming nausea and vomiting related to of motion sickness, drastically diminishing symptoms.


  • Careddu, P. (1986). Treatment of periodic acetonemic vomiting: comparison of drugs. Unpublished Pharmaton Report.
  • Grontved, A., Brask, T., Kambskard, J., Hentzer, E. (1988) Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol 105(1-2): p. 45-9.
  • Holtmann, S., Clarke, A. H., Scherer, H., Hohn, M (1989) The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate. Acta Otolaryngol 108(3-4): p. 168-74.
  • Kirchdorfer, A.M., Heister, R. (1983). Report on a field study with Zintona in the prophylaxis and treatment of motion sickness. Unpublished Pharmaton Report.
  • Lien, H. C., Sun, W. M., Chen, Y H, Kim H., Hasler, W., Owyang C. (2003) Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol
  • Gastrointest Liver Physiol 284(3): G481-9.
  • Mowrey, D.B., Clayson,D.E. (1982) Motion sickness, Ginger, and Psychophysics. Lancet 1 (8273): p. 655-7.
  • Riebenfeld, D., Borzone, L. (1986). Randomized double-blind study to compare the activities and tolerability of Zintona and dimenhydrinate in 60 subjects with motion sickness. Unpublished Pharmaton Report.
  • Schmid, R., Singh, J., Khamesra, R., Bordia, A. (1994). Comparison of Seven Commonly Used Agents for Prophylaxis of Seasickness. J Travel Medicine 1(4): 203-206.
  • Stewart, J.J., Wood, M.J., Wood, C.D., Mims, M.E. (1991). Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 42, 111-120.
  • Wood, C.D., Manno, J. E., Wood, M. J., Manno, B. R., Mims, M. E (1988) Comparison of Efficacy of Ginger with Various Antimotion Sickness Drugs. Clinical Research and Regulatory Affairs 6(2): p. 129-136.